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apalutamide will reduce the extent or effect of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Coadministration of apalutamide, a powerful CYP3A4 inducer, with medication which are CYP3A4 substrates may result in reduce publicity to those medications.Nonetheless, the waking mechanism of mo